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Do All the New Injectables Have You Confused? Dr. Fredric Brandt fills you In ... by Dr. Frederic Brandt (press release) Famed dermatologist, Dr. Fredric Brandt, is always at the forefront of dermatological advances. As the number one user of botox and collagen in the world, Dr. Brandt is the authority on non-invasive cosmetic treatments.

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Press release from Dr. Frederic Brandt (April 16, 2003)

NEW YORK, (April 16)-- Famed dermatologist, Dr. Fredric Brandt, is always at the forefront of dermatological advances. As the number one user of botox and collagen in the world, Dr. Brandt is the authority on non-invasive cosmetic treatments. His renowned expertise in this field has earned Dr. Brandt a position as a clinical research investigator and spokesperson for Collagen Corporation (INAMED), and Allergan (creators of Botox) and a spot on the advisory board of Q-Med (makers of Restylane). Now, the producers of the next generation of injectables have turned to Dr. Brandt to be one of the first to test the newest injectables slated to hit the US market. Dr. Brandt conducted initial clinical trials with Cosmoderm, Cosmoplast and Restylane and thoroughly investigated all preliminary data associated with Artecoll and Radiance. Here, Dr. Brandt explains the differences, benefits, and risks, and gives insider information on these latest filler injectables.

COSMODERM AND COSMOPLAST

Manufactured by INAMED, Cosmoderm and Cosmoplast are revolutionary filler materials that just received FDA approval on March 12, 2003. Cosmoderm is a thin material that is used for finer lines and Cosmoplast, which contains glutaraldehyde for more viscosity, is thicker and is used for deeper lines. These materials are the only collagen dermofillers that are derived in a lab, which eliminates the possibility of a viral or bacterial disease transmission.

"The major advantage of Cosmoderm and Cosmoplast is that, unlike regular collagen, patients are not required to be skin tested prior to injection," says Dr. Brandt. "Because these filler forms are all-natural, human-derived products, patients cannot develop a reaction or allergy to them and don't have to undergo a waiting period to determine how their skin will react," he explains.

RESTYLANE

Restylane, a product of Q-Med and distributed by Medicis, is made of hyaluronic acid, a sugar-based gel, which is naturally present in the skin and joints of all living organisms. As a natural element, this means that the material eliminates the potential for any allergic reaction and poses no risk for transmission of disease. The gel is used to diminish deep as well as, fine lines and wrinkles and to enhance the lip area by working with the body's own hyaluronic acid to create volume much like natural fat tissue does.

According to Dr. Brandt, "The clinical study's results indicate that Restylane's line diminishing capabilities are superior to other injectables on the market such as Zyplast collagen. Of the patients that participated in the trial, more than half had a better remaining effect from the treatment with Restylane than with the compared products; additionally Restylane is longer lasting than collagen." The most widely used injectable filling product in Europe and Canada, Restylane is due for FDA approval in the United States very shortly.

ARTECOLL

Manufactured by Artes Medical, Inc., Artecoll(R) is an injectable micro-implant used for the persistent correction of facial wrinkles, lines, and furrows. Since its introduction in 1994, Artecoll has been used in over 200,000 patients outside the United States, including Europe, South America, Mexico and Canada, and is soon to get FDA approval in the United States. The Artecoll implant consists of 75% bovine collagen solution and 25% polymethylmethacrylate (PMMA) microspheres (synthetic bubbles), which make the material round, smooth and airy.

Artecoll injections contain microspheres that work to stimulate the natural development of human collagen. The body's newly produced collagen is then formed around the injected microspheres. The plumping effect, which takes approximately 3-6 months, is achieved through the combination of the natural collagen that is now mixed in with the plumping microspheres. "The major benefit of the material is that it is long-lasting," says Dr. Brandt. "However, because the PMMA microspheres are permanent in the skin once injected, any negative reactions or lumpiness that might occur will also be permanent." Additionally, some delayed reactions to Artecoll have also been reported.

RADIANCE

Manufactured by BioForm, Inc., Radiance is a long-lasting soft tissue filler that lasts up to 3 to 5 years and is currently FDA approved to treat human vocal cord paralysis only. Radiance consists of calcium hydroxiapatite (CaHA), a primary component of teeth and bones. It is supplied in an injectable form and remains soft, pliable and non-calcified. There have been no reported side effects or allergic reactions and it does not require skin testing. Once injected into the tissue, Radiance takes on the characteristic of the surrounding tissue: hard when on bone and soft when in fat.

The advantage of this product over other types of fillers, such as collagen, is that it requires no skin testing and can last significantly longer. And while its positive effects last up to five years, so do its negative effects, which often include asymmetry of the skin or lumpiness. According to Dr. Brandt, "More research and clinical studies should be conducted on this material in the United States to reach a comfort level where it can be widely used."

SOURCE Dr. Frederic Brandt

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